Prof. Sébastien Lecommandoux
Université de Bordeaux


Biomimetic Polymer Vesicles: Virus and Cell Mimics towards innovative biomaterials


Polymersomes (polymer vesicles) are among the most attractive systems for drug delivery applications. We report here an overview on the self-assembly in water of amphiphilic block copolymers into polymersomes, and their applications in loading and controlled release of both hydrophilic and hydrophobic molecules and biomolecules.
We pay special attention to polysaccharide and polypeptide-based block copolymer vesicles and their development in nanomedicine. These copolymers that mimic the structure and some function of glycoproteins on virus represent an example of the effectiveness of a biomimetic strategy in implementing materials design. We especially evidenced the particular benefit of nanoparticles and their multivalency toward the interaction with biological receptors.
Finally, our recent advances in using “biomimicry approaches” to design complex, compartmentalized and functional protocells will be proposed. Such a system constitutes a first step towards the challenge of structural cell mimicry and functionality.


Sebastien Lecommandoux is currently Director of the “Laboratoire de Chimie des Polymères Organiques” (LCPO) and leading the group “Polymer Self-Assembly and Life Sciences”. His research interests include polypeptide and polysaccharide based block copolymers self-assembly, biomimetic approaches toward design of synthetic viruses and cells as well as the design of polymersomes for drug-delivery and theranostic. He is especially recognized for the design of original polymeric nanoparticles, “bioactive by design” and stimuli responsive, able to load and release “on demand” molecular and biomacromolecular drugs (anti-cancer, peptide,…). He published more than 170 publications in international journal, 6 book chapters and 4 patents, with over 8000 citations (h-factor 43, wos). He recently chaired the ESF Research Network Programme on “Precision Polymer materials” P2M and in the board of the French Society of Nanomedicine (SFNano). He is Associate Editor for Biomacromolecules (ACS) and in the Editorial Advisory Board of several international journals, including Bioconjugate Chemistry (ACS), Polymer Chemistry and Biomaterials Science (RSC).