This talk will illustrate why and how being attached to a nanoparticle influences the interaction between biological molecules. DNA-tagged gold nanoparticles are used as model system to demonstrate the concept of attinebility (higher apparent affinity). Also the application potential of this technology will be presented by counting short RNA sequences in a sample without PCR.
Bio
János Vörös is a Professor in the Institute for Biomedical Engineering of the University and ETH Zurich (Department for Information Technology and Electrical Engineering) heading the Laboratory for Biosensors and Bioelectronics since 2006.
János Vörös has studied Physics at the Eötvös Loránd University in Budapest. After receiving a diploma in Physics in 1995, he was a doctoral student at the Department of Biological Physics of the Eötvös University (in collaboration with Microvacuum Ltd.) where he received his PhD in Biophysics in 2000. Since 1998 he was a member of the BioInterface group in the Laboratory for Surface Science and Technology at the Department of Materials of ETH Zurich as visiting scientist, postdoc, and from 2004 as group leader of the Dynamic BioInterfaces group until 2006. Prof. Vörös also has an adjunct appointment at the Department of Engineering Science and Mechanics of the Pennsylvania State University.
Prof. Vörös is interested in research and teaching in the areas of Biosensors, Bioelectronics, Nano-Biotechnology, Biophysics, Biomaterials and Neurosciences with special focus on the understanding, monitoring and controlling of molecular and cellular processes at biological interfaces. His research group focuses on the development of novel biosensor techniques for diagnostics and drug discovery; on using nanobiotechnology for interfacing neural networks; as well as on implanted stretchable electronic devices.