Atomically thin nanopore membranes are considered to be a promising approach to achieve single base resolution with the ultimate aim of rapid and cheap DNA sequencing. Recently, we made advances in using nanopore platform for its integration with 2 D materials such as graphene or MoS₂. Translocation of various types of DNA exhibits a signal amplitude that is five times higher than in the case of solid-state Si₃N₄ membranes and a SNR of more than 10. These features are highly desirable for event detection and we take advantage of them by showing the electric-field induced unfolding of a 48 kbp long DNA molecule within the nanopore which manifests itself in the quantization of the current drop. Unlike graphene nanopores, no special surface treatment is needed to avoid strong interaction between DNA and the surface. Our results imply that MoS₂ nanopore membranes can compete with graphene nanopore membranes in terms of spatial resolution and possibly better performance for transverse detection. Finally I will introduce our approach to slow down DNA translocations through MoS2 nanopore.

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Bio

Prof. Dr. Aleksandra Radenovic is assistant Professor at the EPFL, Laboratory of Nanoscale Biology since 2008. She studied Physics at the University of Zagreb and received her PhD from the University of Lausanne. She occupied a Postdoc position at the University of California, Berkeley. Her research interests focus on nanofabricated structures to study biomolecular systems.